BOH Agenda 032520 - Laserfiche WebLink

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did not allow for quantitation. This suggestive effect appeared greater in adults than during development. The OHAT review stated most all studies suffered from key deficiencies, including problems with study design, statistics, bias, reporting, method descriptions, etc. Overall the conclusions of this review indicate the pool of available rodent data linking fluoride exposure with neurotoxicity is at best only suggestive, that it comes from studies that most all suffer from key and serious issues, and that it provides no evidence that it occurs at levels used for community water fluoridation. Conclusion: At present available data from studies in humans and rodents are consistent in indicating that fluoride, when used and consumed at the levels recommended for community water supplementation (0.7 mg/L), is not associated with neurotoxic effects. This includes systematic reviews of adverse effects in humans and rodents, which combine studies to help better define patterns. At high levels of exposure to fluoride there are data that provide some suggestive evidence of neurotoxicity, but these studies consistently have had confounding factors (human: unknown rigor, exposure to other neurotoxins, diet, etc.; rodent: problems with study design, statistics, bias, reporting, method descriptions, etc.) that overall seriously undercut any firm conclusion about fluoride exposure and neurotoxicity. Indeed one can readily find recent, well performed studies in humans that provide strong evidence that fluoride exposure does not cause neurotoxicity (for example: Barberio et al., 20171). References: 1. Barberio, et al., 2017: Fluoride exposure and reported learning disability diagnosis among Canadian children: Implications for community water fluoridation. Can. J. Public Health. 14;108:e229-e239. 2. Bashash et al., 2017: Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 years of Age in Mexico. https://doi.org/10.1289/EHP655. 38