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association of increased joint pain and low-level exposure to fluoride is not clearly supported <br /> by these studies. <br /> References: <br /> I. Community Water Fluoridation Programs: A Health Technology Assessment—Review of Dental <br /> Caries and Other Health Outcomes. Ottawa: CADTH 2O19 Feb. (CADTH technology review; <br /> no. 12) https://www.cadth.ca/sites/default/files/pdf/HT0022%20CWF%20- <br /> %20Clinical%20report.pdf <br /> 2. Levy M, Leclerc BS. Fluoride in drinking water and osteosarcoma incidence rates in the <br /> continental United States among children and adolescents. Cancer Epidemiol. <br /> 2012;36(2):e83-e88. doi:10.1016A.canep.2011.11.008 <br /> 3. Blakely K, Feltbower RG, Parslow RC, et al. Is fluoride a risk factor for bone cancer? Small area <br /> analysis of osteosarcoma and Ewing sarcoma diagnosed among 0-49-year-olds in Great <br /> Britain, 1980- 2005. Int J Epidemiol. 2014;43(1):224-234. doi:10.1093/ije/dyt259 <br /> 4. Six-Year Review 3 - Health Effects Assessment for Existing Chemical and Radionuclide National <br /> Primary Drinking Water Regulations - Summary Report, Appendix C Health Effects of <br /> Fluoride. US Environmental Protection Agency, December 2016. <br /> https://www.epa.gov/sites/production/files/2016-12/documents/822r]6008.[)df <br /> 5. Bassin, E.B., Wypij D., Davis R.B., Mittleman M.A. 2006. "Age-specific Fluoride Exposure in <br /> Drinking Water and Osteosarcoma." Cancer Causes and Control 17: 421-8 <br /> 6. Kim, F. M., C. Hayes, P. L. Williams, G. M. Whitford, K. J. Joshipura, R. N. Hoover, C. W. Douglass, <br /> M. C. Gebhardt, M. T. Scarborough, S. Gitelis, J. J. Eckardt, J. R. Neff, M. J. Joyce, M. <br /> Malawer, M. Mcguire, and H. C. Anderson. 2011. An Assessment of Bone Fluoride and <br /> Osteosarcoma. Journal of Dental Research 90.10: 1171-176. <br /> 21 <br />