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7 <br /> excessive sitters were still 34 percent more likely to develop heart failure than those who <br /> were standing or moving. <br /> Reduced Risk of Cancer <br /> A handful of studies have suggested that extended periods of sitting can be linked with <br /> K f ,i ��� t n �u,. :i'. Breast and colon cancer appear to be most <br /> II II �'�„ n 1� IC.II"�a I B�� "��', � IC A� �.� <br /> influenced by physical activity(or lack thereof) a') �,��A 11..a1......a d...111ji(..]y found that prolonged <br /> sitting could be responsible for as much as 49,000 cases of breast cancer and 43,000 <br /> cases of colon cancer annually in the U.S. But the same research found that significant <br /> amounts of lung cancer (37,200 cases), prostate cancer (3o,600 cases), endometrial <br /> cancer (12,000 cases) and ovarian cancer (1,800 cases) could also be related to excessive <br /> sitting. <br /> The underlying mechanism by which sitting increases cancer risk is still unclear, but <br /> scientists have found a number of biomarkers, such as ;; E���°d 9..v 1)En:�..b� ,;u„ that are <br /> present in higher levels in people who sit for long periods of time. These may be tied to <br /> the development of cancer. <br /> Lower Long-Term Mortality Risk <br /> Because of the reduced chance of obesity, diabetes, cardiovascular disease and cancer, a <br /> number of studies have found strong correlations between the amount of time a person <br /> spends sitting and his or her chance of dying within a given period of time. <br /> '. A a� . ..... .:!L.li..°.a..p...ir.,)...:..n............°.a..p...�!!��al.(..j�v, for instance, found that for each extra hour participants spent <br /> sitting daily, their overall risk of dying during the study period (seven years) increased <br /> by 11 percent / m..i °..� 111j(]y found that if the average American reduced his or her sitting <br /> time to three hours per day, life expectancy would climb by two years. <br /> These projects control for other factors such as diet and exercise—indicating that sitting, <br /> in isolation, can lead to a variety of health problems and increase the overall risk of <br /> death, even if you try to get exercise while you're not sitting and eat a healthy diet. And <br /> though there are many situations besides the office in which we sit for extended periods <br /> (driving and watching TV, for instance, are at the top of the list), spending some of your <br /> time at work at a standing desk is one of the most direct solutions. <br />